Cardiac Conditions Associated With Bacterial Endocarditis Reported By The American Heart Association

  1. High-Risk Category-endocarditis prophylaxis recommended
    • Prosthetic cardiac valves, including bioprosthetic and homograft valves
    • Previous bacterial endocarditis complex cyanotic congenital heart disease (e.g., single ventricle states, transposition of the great arteries, tetralogy of Fallot)
    • Surgically constructed systemic pulmonary shunts or conduits
  2. Moderate-Risk Category-endocarditis prophylaxis recommended
    • Most other congenital cardiac malformations (other than above or below)
    • Acquired valvular dysfunction (e.g., rheumatic heart disease)
    • Hypertrophic cardiomyopathy
    • Mitral valve prolapse with valvar regurgitation and/or thickened leaflets
  3. Negligible-Risk Category-no greater risk than the general population-endocarditis prophylaxis not recommended
    • Isolated secundum atrial septal defect
    • Surgical repair of atrial septal defect, ventricular septal defect or patent ductus arteriosus (without residua beyond six months)
    • Previous coronary artery bypass graft surgery
    • Mitral valve prolapse without valvar regurgitation
    • Physiological functional or innocent heart murmurs
    • Previous Kawasaki disease without valvar dysfunction
    • Previous rheumatic fever without valvar dysfunction
    • Cardiac pacemakers (intravascular and epicardial) and implanted defibrillators
  4. The American Heart Association protocols should be followed for those categories recommended — high-risk category and moderate-risk category.